::: Pakistan Armed Forces Medical Journal :::
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چکیده
Objective: To compare the frequency of recurrence and corneoscleral complications with pre-operative and intraoperative mitomycin C when used with excision of primary pterygium by bare sclera technique. Study Design: Quasi experimental study. Place of Study: Armed Forces Institute of Ophthalmology Rawalpindi Duration of Study: Ten months (October 2006 to July 2007). Patients and Methods: A total of 70 cases with primary pterygium were selected and divided equally into group A and B. In cases of group A, 0.1cc of 0.15 mg/ml of MMC was injected sub-conjunctivally and pterygium excision with bare sclera technique was done 4 weeks later. In cases of group B, after removing the pterygium by bare sclera technique, a sponge soaked in 0.04% MMC was applied over the bare sclera for three minutes intraoperatively. The patients were followed up to see recurrence and corneoscleral complications for three months. Results: A total of 70 cases, 35 in each group were analyzed statistically. Mean age of group A was 40.83±12.655 years whereas that of group B was 44.57±13.718 years. Group A had 28 (80%) males and 7 (20%) females. Group B had 23 (65.7%) males and 12 (34.3%) females. Number of patients who presented with recurrence in group A was 1 (2.9%) and group B were 4 (11.4%). In group A no patient presented with corneoscleral complications during the study whereas in group B these complications were seen in 7 (20%). Chi-square test revealed no significant difference in recurrence (P=0.356) whereas it showed significant difference in corneoscleral complications between the groups (P=0.011). Conclusion: Preoperative MMC is as effective as intraoperative MMC in preventing recurrence but it is much safer than intraoperative MMC causing less corneoscleral complications.
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